Custodians of Memory: A history of American archival science with suggestions for future digital preservation efforts

The archive and the historian are symbiotically dependent on one another. The archive relies on the historian to make use of the records it houses, and the historian looks to the archive to reconstruct history. But can a historian responsibly reconstruct history when the archive is fraught with relativity and bias? This thesis serves two purposes; one, pulling from seminal archival science and collections management texts, it chronicles the monumental, intellectual changes to American archival sciences, theories, and institutions, and two, it shows how these early conversations pertaining to archival theories are both not far removed from digital preservation efforts and at times incompatible with the unique non-analogous problems created by web-born sources. But as this thesis argues, theoretical offerings are not always the most implementable for archives; the crux of archival science has historically and contemporarily been responsibility versus practicality, particularly in regard to appraisal theory. These problems exacerbate in the digital realm where the sheer amount of records and material produced by the second warrants extremely narrow but careful collecting. To not add to the overwhelming problem of digital appraisal theory, this thesis offers tangible solutions to help mitigate irresponsible collecting practices

A Contemporary Witch Hunt: The McCarthy Era at Cal Poly

The Second Red Scare, starting in 1947, continuing through the 1950s and into the early 1960s, can be described as a contemporary witch hunt. McCarthyism, described as “a method, a tactic, an attitude, a tendency, a mood, a hysteria, an ideology, and a philosophy,” was in full force as Senator Joseph R. McCarthy began to play on the panic the public felt regarding the USSR and communism. McCarthy dedicated five years attempting to expose communists and other “left-wing loyalty risks” within the U.S. government. Due to the “hyper-suspicious atmosphere” of the Cold War, even insinuating disloyalty was enough to convince Americans that their government was packed with Commies and Reds. McCarthy’s accusations were so intimidating that few people dared to speak out against him. It was not until he attacked the Army in 1954 that his actions earned him the censure of the U.S. Senate. And though he was removed from politics in the mid-1950s, the hysterics revolving around labeling supposed “Communists” began to infiltrate many institutions, including the university systems in the United States. Due to McCarthy’s reckless allegations, many professors, administrators, and students fell victim to the plague of McCarthyism. Thomas C. Reeves, “McCarthyism: Interpretations since Hofstadter,” The Wisconsin Magazine of History, Vol. 60, No. 1 (Autumn, 1976): 47, accessed January 31, 2016, http://www.jstor.org.ezproxy.lib.calpoly.edu/stable/463509

Links between traumatic brain injury and ballistic pressure waves originating in the thoracic cavity and extremities

Identifying patients at risk of traumatic brain injury (TBI) is important because research suggests prophylactic treatments to reduce risk of long-term sequelae. Blast pressure waves can cause TBI without penetrating wounds or blunt force trauma. Similarly, bullet impacts distant from the brain can produce pressure waves sufficient to cause mild to moderate TBI. The fluid percussion model of TBI shows that pressure impulses of 15-30 psi cause mild to moderate TBI in laboratory animals. In pigs and dogs, bullet impacts to the thigh produce pressure waves in the brain of 18-45 psi and measurable injury to neurons and neuroglia. Analyses of research in goats and epidemiological data from shooting events involving humans show high correlations (r > 0.9) between rapid incapacitation and pressure wave magnitude in the thoracic cavity. A case study has documented epilepsy resulting from a pressure wave without the bullet directly hitting the brain. Taken together, these results support the hypothesis that bullet impacts distant from the brain produce pressure waves that travel to the brain and can retain sufficient magnitude to induce brain injury. The link to long-term sequelae could be investigated via epidemiological studies of patients who were gunshot in the chest to determine whether they experience elevated rates of epilepsy and other neurological sequelae

Mechanical Test Methods for Assessing Porcine Carotid and Uterine Artery Burst Pressure Following Ex Vivo Ultrasonic Ligature Seal and Transection

A test method was developed to identify those variables important for assessing the performance of ultrasonic surgical devices in ex vivo ligature sealing of porcine carotid and uterine arteries. Ruggedness testing using a small sample size in pilot experiments was conducted using a newly developed test method in an effort to assess the usefulness of this methodology and to identify test variables that might warrant further testing. The development of this test method included the use of a custom-designed prototypic tension device for load-controlled ex vivo vessel stretching during saline perfusion and subsequent seal and transection of porcine arteries with an advanced energy surgical device. The quality of the seal was evaluated as a burst pressure (mmHg). The experimental set-up allowed for either monitoring or controlling specific test conditions, including blood vessel tension during cutting and sealing, saline infusion rate, cutting time, pressure generated in the vessel during cutting, and burst pressure. Both muscular-type uterine and elastic-type carotid arteries were investigated, since energy based devices are most frequently used on muscular-type arteries but are developed and tested using elastic-type arteries. Although confounded with the age of the animal, in the ruggedness test pilot, it was observed that porcine carotid arteries yielded a comparatively lower burst strength seal as compared to porcine uterine arteries. The data generated during ruggedness testing suggests that the artery type and saline infusion rate during transection may be important variables in ex vivo vessel seal testing

Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods

The Metabolic Syndrome (MetSyn), which is a clustering of traits including insulin resistance, obesity, hypertension and dyslipidemia, is estimated to have a substantial genetic component, yet few specific genetic targets have been identified. Factor analysis, a sub-type of structural equation modeling (SEM), has been used to model the complex relationships in MetSyn. Therefore, we aimed to define the genetic determinants of MetSyn in the Framingham Heart Study (Offspring Cohort, Exam 7) using the Affymetrix 50 k Human Gene Panel and three different approaches: 1) an association-based "one-SNP-at-a-time" analysis with MetSyn as a binary trait using the World Health Organization criteria; 2) an association-based "one-SNP-at-a-time" analysis with MetSyn as a continuous trait using second-order factor scores derived from four first-order factors; and, 3) a multivariate SEM analysis with MetSyn as a continuous, second-order factor modeled with multiple putative genes, which were represented by latent constructs defined using multiple SNPs in each gene. Results were similar between approaches in that CSMD1 SNPs were associated with MetSyn in Approaches 1 and 2; however, the effects of CSMD1 diminished in Approach 3 when modeled simultaneously with six other genes, most notably CETP and STARD13, which were strongly associated with the Lipids and MetSyn factors, respectively. We conclude that modeling multiple genes as latent constructs on first-order trait factors, most proximal to the gene's function with limited paths directly from genes to the second-order MetSyn factor, using SEM is the most viable approach toward understanding overall gene variation effects in the presence of multiple putative SNPs

Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation.

Methamphetamine (MA) is a highly addictive psychomotor stimulant, with life-time prevalence rates of abuse ranging from 5-10% world-wide. Yet, a paucity of research exists regarding MA addiction vulnerability/resiliency and neurobiological mediators of the transition to addiction that might occur upon repeated low-dose MA exposure, more characteristic of early drug use. As stimulant-elicited neuroplasticity within dopamine neurons innervating the nucleus accumbens (NAC) and prefrontal cortex (PFC) is theorized as central for addiction-related behavioral anomalies, we used a multi-disciplinary research approach in mice to examine the interactions between sub-toxic MA dosing, motivation for MA and mesocorticolimbic monoamines. Biochemical studies of C57BL/6J (B6) mice revealed short- (1 day), as well as longer-term (21 days), changes in extracellular dopamine, DAT and/or D2 receptors during withdrawal from 10, once daily, 2 mg/kg MA injections. Follow-up biochemical studies conducted in mice selectively bred for high vs. low MA drinking (respectively, MAHDR vs. MALDR mice), provided novel support for anomalies in mesocorticolimbic dopamine as a correlate of genetic vulnerability to high MA intake. Finally, neuropharmacological targeting of NAC dopamine in MA-treated B6 mice demonstrated a bi-directional regulation of MA-induced place-conditioning. These results extend extant literature for MA neurotoxicity by demonstrating that even subchronic exposure to relatively low MA doses are sufficient to elicit relatively long-lasting changes in mesocorticolimbic dopamine and that drug-induced or idiopathic anomalies in mesocorticolimbic dopamine may underpin vulnerability/resiliency to MA addiction

Nine Strategies to Guide Efforts to Reduce Youth Gun Violence

Gun violence, including that perpetrated by young people, is a pernicious problem for many communities, particularly those facing historically high levels of concentrated disadvantage and disinvestment. To effectively address youth gun violence and establish and maintain peace, communities need stable safety infrastructures and effective interventions.We developed a research-based practice guide to help local governments, law enforcement agencies, and antiviolence organizations determine how to shape their approaches to reducing gun violence perpetrated by young people ages 10 to 25 in gangs or groups. Here, we summarize the guide's recommendations on how to develop effective interventions and build a broader safety infrastructure that supports the success of different partners working to protect young people and communities from gun violence

A Research-Based Practice Guide to Reduce Youth Gun and Gang/Group Violence

While extensive research exists, the field lacks a current and translational synthesis of what works to reduce youth group and gun violence. In response, the Urban Institute developed a research-based practice guide to inform local government, law enforcement, and community-violence-intervention stakeholders as they implement new antiviolence interventions and refine existing ones. To inform the development of the guide, Urban researchers conducted a comprehensive literature synthesis of research on violence reduction interventions and conducted a scan of interventions representing well-known antiviolence models and other innovative strategies. Drawing on the findings from the literature synthesis and scan of practice, the practice guide presents recommendations around nine practice areas related to building an infrastructure to support a multi-faceted antiviolence strategy and implementing effective violence reduction programs